Recent Publication from Metallo Group
Posted in News Story
Professor Steven Metallo of the ISMSM and his group recently published a paper, “Portability of a Small-Molecule Binding Site between Disordered Proteins” in Biomolecules. The research investigates the nature of small-molecule binding sites in intrinsically disordered proteins (IDPs) by transferring a short, small-molecule binding sequence derived from the c-Myc protein into another disordered protein. The group found that the sites were portable and retained binding function but that residues outside the binding site can have opposing effects on binding affinity depending on the broader protein context.