In the Blair-lab we are investigating the structure and mechanical properties of soft and biological materials. These materials are often found in disordered and geometrically frustrated configurations that are far from thermal equilibrium. We are particularly interested in how these materials respond to bulk and localized stresses and strains. Using advanced microscopy techniques, such as laser scanning confocal microscopy, coupled with simultaneous rheological measurements, we investigate the interplay between the structure and the dynamics of these materials as they are driven. Insights gained from our experiments will provide insights in many different practical and fundamental materials.